PySimpleGUI

Launched in 2018 Actively developed and supported. tkinter and Qt supported. Super-simple to create custom layout GUI's. Python 2.7 & 3 Support. 100 Demo programs & Cookbook for rapid start. Extensive documentation. Examples using Machine Learning(GUI, OpenCV Integration, Chatterbot), Floating Desktop Widgets, Matplotlib + Pyplot integration, add GUI to command line scripts, PDF & Image Viewer. Great for beginners as well as advanced GUI programmers..